Several ppl said they wanted to see my keybinds.  I have a few spells set up as keybinds, but for the most part - I use clique.

Clique is a great add on that allows you to just move your mouse pointer over a players square in grid and press a button on your mouse or a combination of keyboard + mouse to instantly cast that spell on that person.

You dont have to select anyone on grid by clicking their square, there is no need to write tons of mouseover macros for every cast on your bar

By using my right hand for mouse control and because my mouse has multiple buttons, I dont even have to press a key on the keyboard with my left hand for many casts - this allows my left hand to be doing other things like moving!

Or if I'm using a shift or alt or control button + mouse button spell thats only using my pinky finger leaving my main fingers free as well. If you are pressing 1,2,3,4 then you are using the fingers on your hand that have the most dexterity which may slow down yoru movement.

Note, my right mouse button is not bound to anything that doesnt require a key press to activate.  This allows normal right mouse button useage so I can also turn/run/strafe while holding down right button - but if I'm moving with the right button pressed down my pinky can drop to the applicable shift/alt/control key and I can cast instants on the run if needed.