http://www.childsplaycharity.org/

As a gamer, the only real charity I give to consistently is Child's Play. Each year, many children's hospitals in the US and Canada create Amazon wish lists, which you can browse, purchase items, and have them mailed directly to the hospital that needs them. Items focus on Games and books, prices ranging from $3 golden books to $200 DS/Wii/Xbox systems, so there's something for everyone's budget. Please stop by and see if there's a hospital in your area that you could give to!

"Since 2003, over 100,000 gamers worldwide
have banded together through Child’s Play, a community based charity
grown and nurtured from the game culture and industry. Over 5 million
dollars in donations of toys, games, books and cash for sick kids in
children’s hospitals across North America and the world have been
collected since our inception.

This year, we have continued expanding across the country and the
globe. With almost 70 partner hospitals and more arriving every month,
you can be sure to find one from the map above that needs your help!
You can choose to purchase requested items from their online retailer
wish lists, or make a cash donation that helps out Child’s Play
hospitals everywhere. Any items purchased through Amazon will be
shipped directly to your hospital of choice, so please be sure to
select their shipping address rather than your own.

When gamers give back, it makes a difference!"

http://www.childsplaycharity.org/